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Pathophysiology of Eosinophilic Esophagitis

Kanak Kennedy,Amanda B. Muir,Melanie A. Ruffner

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA（2024）

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Abstract
Eosinophilic esophagitis (EoE) is a chronic, progressive immune-mediated disease associated with antigen-driven type 2 inflammation and symptoms of esophageal dysfunction. Research over the last 2 decades has dramatically furthered our understanding of the complex interplay between genetics, environmental exposures, and cellular and molecular interactions involved in EoE. This review provides an overview of our current understanding of EoE pathogenesis.
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Key words
Eosinophil,Esophagitis,Etiology,Pathogenesis,Food allergy,Genetics,Epithelium
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