Effectiveness of dextranomer/hyaluronic acid copolymer injection in pediatric population with vesicoureteric reflux having associated congenital anomalies: our experience and detailed review

Successful resolution of vesicoureteric reflux (VUR) via endoscopic methods has been achieved in the last two decades. After investigating multiple agents, Deflux is being used at most of the centers. We have studied the safety and efficacy of Deflux in our patients having VUR with complex urogenital anomalies and reviewed the literature. We have retrospectively collected the data of 28 children with the diagnosis of VUR, treated endoscopically over a period of 3 years. The data were collected from the hospital records and analyzed. The data included demographics, associated anomalies, grades of reflux, number of ureters affected, treatment given, number of sittings required, initial findings of micturating cystourethrograms, follow-up cystogram findings, and details of the procedure done. The data were evaluated for overall success rates in children with associated anomalies. Among the 28 patients, 22 children with 33 affected ureter units having associated anomalies (secondary VUR) were included in the study, with 18 boys and 4 girls. Six children having primary VUR and not associated with other congenital anomalies were excluded. The reflux was unilateral in 10 (45.45