Advances in Systemic Therapy in Pancreatic Cancer
Hematology/Oncology Clinics of North America(2024)
摘要
Substantial progress has been made toward understanding biology and developing new therapies for pancreatic ductal adenocarcinoma (PDAC). In this review, new insights from genomic profiling, as well as implications for treatment and prognosis, are discussed. New standards of care approaches with a focus on drug therapies are discussed for the treatment of resectable and advanced PDAC. The role of targeted and immune therapies remains limited; cohorts likely to benefit from these approaches are discussed. Promising, preliminary results regarding experimental therapies are reviewed.
更多查看译文
关键词
Pancreatic adenocarcinoma,DNA damage repair,Mismatch repair,Kirsten rat sarcoma viral oncogene homolog (KRAS),Immunotherapy,poly(adenosine diphosphate-ribose) polymerase (PARP)
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要