FIGURE 5 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate

VCAN, CS, and CS-proteoglycans in different phenotypes. IHC completed for VCAN and CS on consecutive sections of 26 TNBC tissues. A, Spread of CS levels across regions in excluded and inflamed tissues. Tissues were analyzed by IHC using the CS56 antibody which can detect both A and C isomers of CS. B, CS and VCAN percentage determined from the same areas of consecutive slides. Correlations determined for stains in each region of excluded and inflamed tissues. Spearman rank correlation. C, IHC staining completed for BGN and DCN on 30 TNBC tissues. Percentage of stains compared between phenotypes and regions. RM one-way ANOVA. *, P < 0.05; **, P < 0.01; ***, P < 0.005; ****, P < 0.001.