Bioinspired electrocatalytic NAD(P)H regeneration

Usually, nicotinamide cofactor (NAD(P)H)-dependent dehydrogenase could catalyze important redox reactions for the synthesis of fine chemicals and important pharmaceuticals, necessitating a secondary enzyme for NAD(P)H regeneration. However, it remains challenging to develop artificial NAD(P)H regeneration route to replace the enzymatic regeneration system. Electrocatalytic NAD(P)H regeneration has aroused extensive interests and could serve the purpose of sustainable biosynthesis by utilizing the green electricity to deliver the reduction equivalents. Here, starting with a conceptual discussion on natural photosynthesis and dehydrogenase catalysis, we summarize the recent progress in bioinspired electrocatalytic NAD(P)H regeneration and provided a tentative outlook for further developments.