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Enantioselective Synthesis of Eight-Membered Lactone Derivatives via Organocatalytic Cascade Reactions

Dong-Sheng Ji, Rui Zhang, Xu-Yan Han, Hai-Long Chai,Yu-Cheng Gu,Xiuqin Hu,Peng-Fei Xu

Organic Chemistry Frontiers（2024）

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Abstract
Enantioselective accessing medium-sized ring compounds with multiple stereocenters is still a formidable task due to the unfavorable entropy effect. We developed a protocol for the enantioselective synthesis of eight-membered lactone...
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