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Case report: Highly response to low-dose brachytherapy in recurrent retroperitoneal leiomyosarcoma with FANCD2 frameshift mutation: a unique case study

Xiao li Liu,Jinxin Zhao,Xue min Di,Guohui Cao,Hongtao Zhang,Juan Wang

FRONTIERS IN ONCOLOGY（2024）

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Abstract
We report a case of recurrent retroperitoneal leiomyosarcoma in a male who achieved a rapid and robust but transient clinical response to low-dose iodine-125 brachytherapy. A FANCD2 frameshift mutation was detected by gene sequencing in the cancerous tissue.
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Key words
retroperitoneal leiomyosarcoma,FANCD2,brachytherapy,radioactive iodine-125,low dose
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