Concomitant Resistance to Cefiderocol and Ceftazidime/Avibactam in Two Carbapenemase-Producing Klebsiella pneumoniae Isolates from Two Lung Transplant Patients

Greta Bellinzona,Cristina Merla,Marta Corbella, Elizabeth Nagy Iskandar,Elena Seminari,Angela Di Matteo,Stefano Gaiarsa,Greta Petazzoni,Davide Sassera,Fausto Baldanti,Aurora Piazza,Patrizia Cambieri

MICROBIAL DRUG RESISTANCE（2023）

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摘要

In this study, we present two cases of Klebsiella pneumoniae, one KPC-33- and one NDM-1-producing, showing resistance to cefiderocol and ceftazidime/avibactam, collected in the intensive care unit of a hospital in Northern Italy from two patients who had recently undergone lung transplantation. Whole-genome sequencing was performed to investigate the molecular features of these strains.

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关键词

cefiderocol,cefiderocol resistance,ceftazidime,avibactam,ceftazidime,avibactam resistance,Klebsiella pneumoniae,co-resistance,virulence factors,KPC mutated,blaKPC-33,blaNDM-1

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