Synthesis of -Undecalactone via Organophotocatalyzed -C-H Alkylation of 1-Octanol using Continuous-Flow Photoreactors

gamma-Undecalactone has a powerful peach aroma and is widely used in the field of flavor and pharmaceutical industry. Herein we report an organophotocatalyzed one-pot approach for the synthesis of gamma-undecalactone from 1octanol and methyl acrylate using continuous-flow photoreactors. By using readily available and inexpensive 4CzIPN as the photocatalyst, the alpha-C-H alkylation reaction can be easily scaled up to 3 mol with a catalyst loading of 0.08 %.