Optimization of Gate Structure for Damageless MicroLED Thin Films in Optogenetic Applications

Flexible MicroLEDs hold great promise as a novel tool for advancing optogenetics, enabling applications in biology. Such applications require the technology to assemble MicroLEDs onto ultra-thin biocompatible films that conform to the delicate and uneven brain and biological tissues. In this study, a batch transfer technique using thermal release sheets is propsed. By optimizing the gate structures that support the hollow structure, a method to transfer MicroLEDs to the film without causing damage is established. It is successfully demonstrated that the flexible MicroLED films, fabricated using this technique, can be placed on the brain surface of transgenic mice and induce neural activity through optogenetic stimulation. Flexible MicroLEDs promise advancements in optogenetic applications. The study introduces a batch transfer method for assembling MicroLEDs onto ultra-thin biocompatible films. Optimization of gate structures supporting the hollow MicroLED array enables damage-free transfer of MicroLED array. The developed MicroLED film is successfully implanted onto the brain tissue of transgenic mice, inducing neural activity through optogenetic stimulation.image (c) 2024 WILEY-VCH GmbH