Bioorthogonal Chemistry at Radboud University: Past, Present and Future

Over the past two decades, bioorthogonal chemistry hasprofoundly impacted various chemistry-related fields, including chemi-cal biology and drug delivery. This transformative progress stems fromcollaborative efforts involving chemists and biologists, underscoringthe importance of interdisciplinary research. In this Account, we pres-ent the developments in bioorthogonal chemistry within our Institutefor Molecules and Materials at Radboud University. The chemistry dis-closed here spans from strained alkynes and alkenes to drug release andbioconjugation strategies, mirroring the extensive scope provided bybioorthogonal chemistry. By reflecting on the chemistry originating atRadboud University, this Account emphasizes that teamwork is essen-tial for driving significant progress in bioorthogonal chemistry.