First Known Human Death After Infection With the Avian Influenza A/H3N8 Virus: Guangdong Province, China, March 2023

Yali Zhuang,Man Wang,Lijun Liang, Yunxia Mao, Kaibin Wang, Shuhuan Yang,Aiping Deng, Kewen Zeng,Yingtao Zhang,Guanting Zhang, Min Kang,Baisheng Li, Meng Zhang, Shinan Ye

CLINICAL INFECTIOUS DISEASES（2024）

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摘要

Here, we report on a case of human infection with the H3N8 avian influenza virus. The patient had multiple myeloma and died of severe infection. Genome analysis showed multiple gene mutations and reassortments without mammalian-adaptive mutations. This suggests that avian influenza (A/H3N8) virus infection could be lethal for immunocompromised persons.

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avian influenza,A/H3N8,human infection,immunodeficiency,fatal case

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