Chromones Modified with 7-Membered Heterocycles: Synthesis and Biological Activity

The present mini-review for the first time summarizes and systematizes all the data available in the literature on the synthesis and properties of chromones modified with 7-membered heterocycles throughout the chemical space around the chromone framework. Most of the 2-, 6-, 7- and 8-hetarylsubstituted.hromones are represented in the patent literature and were obtained by nucleophilic substitution in the chromone core with a cyclic amine moiety. Methods for the synthesis of heterocyclic analogs of isoflavones are mainly based on 3-formylchromone, its derivatives, chromonylchalcones and by means of multicomponent reactions. The biological activity of chromones substituted with 7-membered heterocycles are also surveyed.