Nanoemulgel as an innovative platform for phytomolecules

The development of herbal remedies in the form of phytoconstituents, bioactive compounds, and extracts for healthcare has piqued the interest of both researchers and medical professionals. Around 80% of the world's population has profited from phytomolecules that consist of numerous attributes, including their nutritious composition and antioxidant, anti-inflammatory, and other therapeutic characteristics. However, lipophilic phytomolecules have various drawbacks, such as poor water solubility, permeability, stability at physiological pH, and poor absorption in GIT, limiting their bioavailability. Nanoemulgel as a good vehicle can overcome the above problems and have better patient compliance due to its noninvasive delivery, high penetration ratio, avoidance of gastrointestinal side effects, easy application, convenient spreadability, and stronger therapeutic and safety features than other topicals. Nanoemulgel is one of the novel topical delivery systems because it has two different release control systems, i.e., hydrogel and nanoemulsion. Due to the finely dispersed oil droplets in the gel phase, lipophilic drugs can be easily incorporated, thus enhancing permeability in several folds that improve the therapeutic efficacy of acne, psoriasis, fungal infection, inflammation, and rheumatoid arthritis. The formulation can also be delivered via ocular, vaginal, dental, and nose-to-brain routes for the treatment of local and systemic ailments such as alopecia, periodontitis, and Parkinson's disease. In the future, nanoemulgel could be recognised as a key and effective formulation for lipophilic drugs. This review highlights the properties, preparation methods, benefits, and characterization of nanoemulgel as a nanocarrier for drug delivery.