Aqueous multicomponent reaction for the synthesis of novel spiro-oxindole derivatives and their antifungal activity

An aqueous three-component reaction of isatin, 4-aminocoumarin, and 1,3-cyclodicarbonyl compound is reported for the synthesis of spiro[chromeno[4,3-b]cyclopenta[e]pyridine-7,3'-indoline]trione and the spiro[chromeno[4,3-b]quinoline 7,3'-indoline]trione. Up to 27 different spiro-oxindole derivatives were synthesized by...