Supplementary Figure S6 from Neutrophils Mediate Protection Against Colitis and Carcinogenesis by Controlling Bacterial Invasion and IL22 Production by γδ T Cells

Figure S6. Neutrophil infiltration is associated with tissue repair gene signatures in patients with ulcerative colitis. Related to Figure 6. A-E) Enrichment plots for gene ontology term epithelial cell (GO:Epithelial Cell Proliferation (A, D); GO:Epithelial Cell Development (B, E); GO:Maintanance of Gastrointestinal Epithilium (C)) in CSF3Rhigh versus CSF3Rlow UC patients GSE109142 (A-C) GSE87473 (D-E). F-K) Enrichment plots for gene ontology term antimicrobial response (GO:Response to molecule of bacterial origin (F, I); GO:Defense response to bacterium; GO:Antimicrobial humoral immune response mediated by antimicrobial peptides) in CSF3Rhigh versus CSF3Rlow UC patients GSE109142 (F-H) and GSE87473 (I-K). CSF3R gene expression values were stratified by quartiles and patients belonging to the upper (GSE109142 n=51; GSE87473 n=21) and lower GSE109142 n=51; GSE97473 n=21) quartiles were considered for differential expression analysis. FDR, false discovery rate.