Focal-to-bilateral tonic-clonic seizures and High-grade CMV-infection are poor survival predictors in Tumor-related Epilepsy Adult-type diffuse gliomas-A single-center study and literature review*

Introduction: Previous studies have reported a correlation between a high-grade CMV-infection and an unfavorable prognosis in glioblastoma (GB). Coversely, epilepsy has been associated with a more favorable outcome in GB patients. Despites epilepsy and CMV share similar molecular mechanisms in GB tumoral microenvironment, the correlation between Tumor-Related-Epilepsy (TRE) and CMVinfection remains unexplored. The aim of our study is to examine the correlation between the dregree of CMV infection and seizure types on the survival of TRE Adult-typediffuse-glioma. To achieve this objective, we conducted a comprehensive literature review to assess our results regarding previous publications Methods: We conducted a retrospective-observational study on TRE Adult-type-diffuse-gliomas treated at a single center in Mexico from 2010 to 2018. Tumor tissue and cDNA were analyzed infected-tumoral cells) and seizure types [Focal awareness, focal impaired awareness, and were male. Fifty percent of the patients presented with mesial involvement of the hemysphere. developmet of epilepsy. Tumor progression could be associated not only with a higher degree of in this group of patients. Further prospective studies are required to validate these results.