Glycolytic activity and in vitro effect of the pyruvate kinase activator AG-946 in red blood cells from low-risk myelodysplastic syndromes patients: A proof-of-concept study

Bruno Fattizzo,Cristina Vercellati, Anna Marcello,Parija Patel,Megan Wind-Rotolo, Loredana Pettine, Marcella Bonanomi,Daniela Gaglio,Marta Bortolotti, Claudia Leoni,Elisa Fermo, Paola Bianchi,Anna Zaninoni,Francesco Passamonti,Wilma Barcellini

AMERICAN JOURNAL OF HEMATOLOGY（2024）

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摘要

Glycolytic activity and in vitro effect of the pyruvate kinase activator AG-946 in red blood cells from low-risk myelodysplastic syndromes patients. Data showed decreased glycolytic activity in red blood cells of 2/3 of patients with lower-risk MDS. These results highlight a potential effect of the PK activator in this setting.

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