Characterization and impact of non-canonical WNT signaling on outcomes of urothelial carcinoma

Margaret Meagher, Harris Krause,Andrew Elliott,Alex Farrell,Emmanuel S. Antonarakis,Bruno Bastos,Elisabeth I. Heath,Christina Jamieson,Tyler F. Stewart,Aditya Bagrodia,Chadi Nabhan, Matt Oberley,Rana R. Mckay,Amirali Salmasi

CANCER MEDICINE（2024）

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摘要

Background: Non-canonical WNT family (WNT5A pathway) signaling via WNT5A through ROR1 and its partner, ROR2, or Frizzled2 (FZD2) is linked to processes driving tumorigenesis and therapy resistance. We utilized a large dataset of urothelial carcinoma (UC) tumors to characterize non-canonical WNT signaling through WNT5A, ROR1, ROR2, or FZD2 expression. Methods: NextGen Sequencing of DNA (592 genes or WES)/RNA (WTS) was performed for 4125 UC tumors submitted to Caris Life Sciences. High and low expression of WNT5A, ROR1, ROR2, and FZD2 was defined as >= top and 更多

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关键词

FZD2,Non-canonical,ROR,Urothelial carcinoma,WNT signaling,WNT5A

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