Characterization and impact of non-canonical WNT signaling on outcomes of urothelial carcinoma
CANCER MEDICINE(2024)
Abstract
Background: Non-canonical WNT family (WNT5A pathway) signaling via WNT5A through ROR1 and its partner, ROR2, or Frizzled2 (FZD2) is linked to processes driving tumorigenesis and therapy resistance. We utilized a large dataset of urothelial carcinoma (UC) tumors to characterize non-canonical WNT signaling through WNT5A, ROR1, ROR2, or FZD2 expression. Methods: NextGen Sequencing of DNA (592 genes or WES)/RNA (WTS) was performed for 4125 UC tumors submitted to Caris Life Sciences. High and low expression of WNT5A, ROR1, ROR2, and FZD2 was defined as >= top and More
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Key words
FZD2,Non-canonical,ROR,Urothelial carcinoma,WNT signaling,WNT5A
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