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脂质代谢异常对帕金森病进程的影响及临床意义

XU Ying,GUI Ya-xing

Chinese Journal of Contemporary Neurology and Neurosurgery（2024）

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Abstract
脂质代谢可能参与帕金森病的发生及进展,涉及α-突触核蛋白异常折叠及积聚、铁死亡、GBA1基因变异、线粒体功能障碍等多种病理生理学机制.本文综述帕金森病的脂质代谢异常以及可能的相关致病机制,为帕金森病的早期诊断与治疗探索新的思路.
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Key words
Parkinson disease,Lipid metabolism,alpha-Synuclein,Glucosylceramidase,Genes,Mutation,Review
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