Determination of sequential adipokine levels in trauma patients followed in the ICU

One of the most common causes of trauma is traffic accidents. Although the death rate is decreasing day by day as a result of trauma-related injuries, the incidence of injury is still very high (1). Morbidity is decreasing due to the development of pre-hospital emergency interventions and the increase of authorized personnel. Likewise, intensive care support is of great importance (2). The aim of the study is to sequentially determine serum adipokine levels in critically ill adult patients followed in the intensive care unit due to trauma. Patients and methods The study was carried out in Erciyes University Medical Faculty Hospital Internal Diseases Intensive Care Unit. Thirty patients aged 18 years and older and 30 healthy volunteers were included in the study. The patients consisted of patients who were admitted to the intensive care unit due to trauma, stayed for at least 7 days, and did not have any chronic diseases. Healthy volunteers were formed to match the age and gender of the patients. In the study, patients' age, gender, height, weight, body mass index, cause of trauma, trauma severity scores, Acute Physiology and Chronic Health Evaluation II (APACHE II) score (3), modified Nutritional Risk in Critically Ill(mNUTRIC) (4) score information received. The patients were followed for 7 days. Sequential Organ Failure Assessment (SOFA) scores (5) and Glasgow coma scores (6) were calculated daily. Mechanical ventilation status, sepsis status, intensive care unit stay, hospital stay and 28-day mortality data were recorded. Results The average BMI value of the patients is25.8 kg/m2. The median mNutric score of the patients was0(0–2). The mean APACHEII score was9.7 ± 5.5. TRISS median was97.8(59–99). Infection occurred in 30% of the patients followed in the intensive care unit, and sepsis occurred in 23%. RH developed in 73% of the patients. The patients stayed in the intensive care unit for a median of 10.5(7–16.25) days. The 28-day mortality rate was 10%. A significant difference was found between the leptin values of healthy individuals and the 3rd day leptin values of the patients (r:0.405 p:0.026). A significant difference was found between the visfatin values of healthy individuals and the visfatin values on the 3rd day(r:0.39 p:0.033) and 7th day(r:0.365 p:0.047) of the patients. Conclusion No significant difference was observed in any group between the baseline and control groups. On the 3rd day of the follow-up, leptin and visfatin values were higher than the control group. On the 7th day of the follow-up, only Visfatin was observed to be significantly higher than the control group.