Hepatoxicity Induced from Exposure of Male Rats to Low Doses of Tributyltin Chloride

Tributyltin (TBT) is a contaminant found all over the world. It is a member of the organotin class, which includes several widely disseminated, very hazardous compounds that have been linked to endocrine disruption. Consumption of TBT-contaminated seafood and drinking water are the most common routes of exposure among the susceptible population to man at low doses. The main goal of this study is to recognize the hepatotoxicity of low doses of TBT chloride (10-2000 µg/Kg body weight) in male rats for 45 days. TBT significantly induce hepatic impairment of antioxidant systems, oxidative stress, lipid peroxidation, and histological abnormalities in the liver architecture. In conclusion: the TBT at low doses could induce hepatotoxicity at low levels due to its lipophilic properties and the ability for accumulation in tissues.