Title：Cross-sectional Examination of the Association Between Life's Essential 8 Score and Overactive Bladder——NHANES 2005-2018

Abstract Objective Life's Essential 8 (LE8) is an emerging composite metric of cardiovascular health encompassing diet, physical activity, smoking, sleep, weight, cholesterol, blood glucose, and blood pressure. Mounting evidence suggests lifestyle factors may play an important role in overactive bladder (OAB), however the link between LE8 and OAB remains unexplored. We aimed to examine the correlation between the two. Methods We analyzed data on 23,187 individuals from the 2005–2018 National Health and Nutrition Examination Survey (NHANES). Participants were stratified into low, moderate and high LE8 groups. Logistic regression examined the association between LE8 and OAB. Restricted cubic splines (RCS) and weighted quantile sum (WQS) regression further probed this relationship. Results Higher LE8 scores were associated with lower OAB risk, independent of covariate adjustment. The inverse correlation between LE8 and OAB was validated by RCS and WQS analyses. Of LE8 components, glycemic control conferred the greatest contribution. Conclusions Higher LE8 scores may be protective against OAB. Optimization of cardiovascular health metrics could represent a novel OAB prevention strategy.