Have We Neglected to Study Target-Site Drug Exposure in Children? A Systematic Review of the Literature

Drug dosing should ideally be based on the drug concentrations at the target site, which, for most drugs, corresponds to the tissue. The exact influence of growth and development on drug tissue distribution is unclear. This systematic review compiles the current knowledge on the tissue distribution of systemically applied drugs in children, with the aim to identify priorities in tissue pharmacokinetic (PK) research in this population. A systematic literature search was performed in the MEDLINE and Embase databases. Forty-two relevant articles were identified, of which 71