Evaluation of aconitine cardiotoxicity with a heart-on-a-particle prepared by a microfluidic device

A heart-on-a-particle model based on multicompartmental microgel is proposed to simulate the heart microenvironment and study the cardiotoxicity of drugs. The relevant microgel was fabricated by a biocompatible microfluidic-based approach, where heart function-related HL-1 and HUVEC cells were arranged in separate compartments. Finally, the mechanism of aconitine-induced heart toxicity was elucidated using mass spectrometry and molecular biotechnology. A heart-on-a-particle model based on a multicompartmental microgel is proposed to simulate the heart microenvironment and study the cardiotoxicity of drugs.