Analysis of efficacy factors in unilateral obstructive severe renal insufficiency

Abstract Objective To investigate the predictors of renal function recovery after treatment of severe renal impairment in unilateral upper urinary tract obstruction (UUTO). Methods From January 2014 to January 2023, the clinical data of 142 patients with unilateral UUTO severe renal injury who were admitted to the First Affiliated Hospital of Chongqing Medical University were collected. The estimated glomerular filtration rate (eGFR) of patients before treatment, GFR value of 99mTc-DTPA dynamic renal scintigraphy before treatment, C-reactive protein before treatment, and body mass index were used as independent variables, a predictive analysis of the change in GFR (GFRd) after treatment. Multiple linear regression analysis was used to predict the GFRd after treatment, and the difference was statistically significant with P < 0.05. At the same time, the categorical variables such as sex, obstruction site and normal renal function were compared with GFRd by two-sample t-test or one-way ANOVA, and the difference was statistically significant with P < 0.05. Results The multiple linear regression results showed that the GFR value of the affected kidney obtained by 99mTc-DTPA dynamic renal scintigraphy and C-reactive protein were significantly correlated with the GFRd value women and patients with renal obstruction had a higher mean GFRd than men and patients with ureteral obstruction, but the difference was not statistically significant. Conclusion The GFR value of the affected kidney obtained by 99mTc-DTPA dynamic renal scintigraphy and C-reactive protein before treatment are important reference indicators for evaluating the efficacy of patients with severe renal insufficiency caused by unilateral upper urinary tract obstruction. And the role of 99mTc-DTPA dynamic renal scintigraphy was irreplaceable when unilateral renal function was impaired or it was necessary to understand unilateral renal function.