FIGURE 1 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases

Expression of SNAIL and PTK6 in TNBC. A, Prognostic significance of SNAIL expression in TNBC. KM survival curves of SNAIL expression in patients with TNBC (defined as estrogen receptor, progesterone receptor, and HER2 negative) using the METBRIC dataset (n = 290) and KM plotter (n = 734). SNAIL expression was divided along the median into low versus high expressors. B, Representative images of IHC staining for PTK6 and SNAIL expression in TNBC tissue microarray (n = 48). Low (0, 1+) and high (2+, 3+) expression was scored by two independent reviewers. C, Expression of PTK6 and SNAIL in triple-negative PDX tumors.