Long Term Mortality in Incident MCI Subtypes. Data from the NEDICES Cohort (P5.213)

OBJECTIVE: To analyze the mortality of mild cognitive impairment (MCI) incident subtypes in the NEDICES (Neurological Disorders in Central Spain) cohort. BACKGROUND: There is scarce information on long term mortality in MCI subtypes. Recently, we published (Eur J Neurol, 2013) the causes of death and mortality in prevalent MCI subtypes and we review the subject. METHODS: The NEDICES cohort is a census population-based survey of elderly (65 and more years) from three sites of Central Spain. The cohort had a basal survey (1994-5) and its evolution and mortality have been follow-up until 2008, with a link with the National Death Spanish Registry. RESULTS: We obtained 2,328 participants in the second follow-up (1997-8), without dementia or prevalent MCI cases. These entire subjects were adequately studied with a MMSE-37 and a normal FAQ of Pfeffer (IADL scale). The majority of them had an extended psychometric evaluation, but the MCI subtypes were performed according to a MMSE-37 paradigm, used in the prevalence study, and they were classified as, non-amnestic (n=428); amnestic-single domain (n=170), amnestic-multiple domain (n=148), and cognitively unimpaired elders (n=1,582). With a mean follow-up of 8.9 years (from 1997-8 until 2008), the mortality of MCI subtypes were respectively: 34.1%, 42.4%, and 55.4%; in the cognitively unimpaired was 34.2%. In a Cox regression adjusted by age, sex, education and co-morbidity, only the amnestic-multiple domain subtype obtained a statistical significant mortality risk, HR(CI95%)=1.61 (1.27-2.05); p<.001. CONCLUSIONS: The long term mortality of MCI subtypes is clearly different, as it was found in other studies, including our previous MCI prevalence mortality. In this cohort, only the amnestic-multiple domain MCI subtype has an increased risk of mortality. Study Supported by: FIS PI 11/1508 and Ciberned. Disclosure: Dr. Bermejo-Pareja has nothing to disclose. Dr. Sanchez-Ferro has nothing to disclose. Dr. Contador Castillo has nothing to disclose. Dr. Boycheva has nothing to disclose. Dr. Trincado has nothing to disclose. Dr. Llamas has nothing to disclose. Dr. Herrero has nothing to disclose. Dr. Sierra has nothing to disclose. Dr. Villarejo Galende has nothing to disclose. Dr. Benito-Leon has nothing to disclose.