Understanding adefovir pharmacokinetics as a component of a transporter phenotyping cocktail

Qian Dong,Chunli Chen,Max Taubert,Muhammad Bilal, Martina Kinzig, Fritz Sörgel,Oliver Scherf-Clavel,Uwe Fuhr, Charalambos Dokos

European Journal of Clinical Pharmacology（2024）

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摘要

Adefovir (as dipivoxil) was selected as a probe drug in a previous transporter cocktail phenotyping study to assess renal organic anion transporter 1 (OAT1), with renal clearance (CLR) as the primary parameter describing renal elimination. An approximately 20

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关键词

Adefovir,Population pharmacokinetics,Nonlinear renal elimination,OAT1-mediated drug-drug interactions

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