18F-FET PET/CT in Calcifying Pseudoneoplasm of the Neuraxis

Abstract A 66-year-old man has been treated in a psychiatric department for 4–5 years for a depressive syndrome, which is associated with poor motor initiative, confusional state, and dysosmia. Dynamic 18F-FET PET/CT showed only faint uptake of radiotracer just above the background on the left frontal calcific lesion. The time-activity curve of the neoplasms showed a descending pattern. After a left fronto-orbitary minicraniotomy surgery, histology examination concluded for a rare calcifying pseudoneoplasm of the neuraxis (CAPNON). To our knowledge, no data are available on the metabolic behavior of CAPNON in 18F-FET PET/CT. This case highlighted that a faint uptake and descending pattern on dynamic 18F-FET PET/CT may be helpful in suspected CAPNON before surgery.