An inhibitory acetylcholine receptor gates context dependent mechanosensory processing in C. elegans

An animal’s current behavior influences its response to sensory stimuli, but the molecular and circuit-level mechanisms of this context-dependent decision-making is not well understood. In the nematode C. elegans , inhibitory feedback from turning associated neurons alter downstream mechanosensory processing to gate the animal’s response to stimuli depending on whether the animal is turning or moving forward [[1][1]–[3][2]]. Until now, the specific neurons and receptors that mediate this inhibitory feedback were not known. We use genetic manipulations, single-cell rescue experiments and high-throughput closed-loop optogenetic perturbations during behavior to reveal the specific neuron and receptor responsible for receiving inhibition and altering sensorimotor processing. An inhibitory acetylcholine gated chloride channel comprised of lgc-47 and acc-1 expressed in neuron RIM receives inhibitory signals from turning neurons and performs the gating that disrupts the worm’s mechanosensory evoked reversal response. ### Competing Interest Statement The authors have declared no competing interest. [1]: #ref-1 [2]: #ref-3