PD-L1 expression and microsatellite instability (MSI) in cancer of unknown primary site
International Journal of Clinical Oncology(2024)
摘要
Cancer of unknown primary site (CUP) is a heterogeneous group of tumors for which the origin remains unknown. Clinical outcomes might be influenced by regulatory processes in its microenvironment. Microsatellite instability (MSI) is a predictive biomarker for cancer immunotherapy and its status, as well as co-occurrence with PD-L1 expression, is poorly evaluated. We aim to evaluate the expression of PD-L1 and the status of MSI in CUP and their possible associations with clinical–pathological features. The combined positive score (CPS) PD-L1 expression was evaluated by immunohistochemistry. MSI status was assessed using a hexa-plex marker panel by polymerase chain reaction followed by fragment analysis. Among the 166 cases, MSI analysis was conclusive in 120, with two cases being MSI positive (1.6
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关键词
Neoplasms,Unknown primary,Microsatellite instability,Immune checkpoint proteins,Immunotherapy
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