Semi-Quantitative Analysis and Seroepidemiological Evidence of Past Dengue Virus Infection among HIV-infected patients in Onitsha, Anambra State, Nigeria

David Nwachukwu, Edith Nnenna Oketah, Chineze Helen Ugwu,Hope Chioma Innocent-Adiele,Chisom Chimbundum Adim, Euslar Nnenna Onu, Ann Onyinyechi Chukwu, Grace Aghaji Nwankwo, Mary Uche Igwe,Phillip O. Okerentugba,Iheanyi Omezuruike Okonko

arxiv(2024)

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摘要
Despite its endemic nature as well as the recent outbreaks, information on the opportunistic DENV in Anambra state has been sparse. This study thus aimed to give seroepidemiological evidence of past dengue virus infection among HIV-infected patients in Onitsha, Anambra State, Nigeria. Plasma from 94 HIV-infected patients who were attending Saint Charles Borromeo Hospital, Onitsha in Anambra State, Nigeria was tested for IgG antibodies specific to the dengue virus by IgG ELISA assay. The prevalence of past dengue virus infection was 61.7 gender (65.1 seropositivity among the study participants. In terms of immunological and virological markers, greater IgG seroprevalence was observed in individuals with a viral load of <40 copies/ml (64.0 (63.2 individuals on Onitsha is cause for concern.
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