Enhancing Positronium Lifetime Imaging through Two-Component Reconstruction in Time-of-Flight Positron Emission Tomography
arxiv(2024)
摘要
Positron Emission Tomography (PET) is a crucial tool in medical imaging,
particularly for diagnosing diseases like cancer and Alzheimer's. The advent of
Positronium Lifetime Imaging (PLI) has opened new avenues for assessing the
tissue micro-environment, which is vital for early-stage disease detection. In
this study, we introduce a two-component reconstruction model for PLI in
Time-of-Flight (TOF) PET, incorporating both ortho-positronium and
para-positronium decays. Our model enhances the accuracy of positronium imaging
by providing a more detailed representation of the tissue environment. We
conducted simulation studies to evaluate the performance of our model and
compared it with existing single-component models. The results demonstrate the
superiority of the two-component model in capturing the intricacies of the
tissue micro-environment, thus paving the way for more precise and informative
PET diagnostics.
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