Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies
Acta Neuropathologica(2024)
摘要
Neurodegenerative pathologies such as Alzheimer disease neuropathologic change (ADNC), Lewy body disease (LBD), limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC), and cerebrovascular disease (CVD) frequently coexist, but little is known about the exact contribution of each pathology to cognitive decline and dementia in subjects with mixed pathologies. We explored the relative cognitive impact of concurrent common and rare neurodegenerative pathologies employing multivariate logistic regression analysis adjusted for age, gender, and level of education. We analyzed a cohort of 6,262 subjects from the National Alzheimer’s Coordinating Center database, ranging from 0 to 6 comorbid neuropathologic findings per individual, where 95.7
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关键词
Alzheimer disease neuropathologic change,Limbic-predominant age-related TDP-43 encephalopathy,Lewy body dementia,Age-related tauopathy,Pick disease,Frontotemporal lobar dementia,Progressive supranuclear palsy,Corticobasal degeneration,Cerebrovascular disease,MMSE,CDR
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