Effect of the drug feronamin on the level of pro- and anti-inflammatory cytokine genes expression in therapy of colibacteriosis in piglets
Transactions of the educational establishment “Vitebsk the Order of “the Badge of Honor” State Academy of Veterinary Medicine(2023)
Abstract
The article presents the data on the level of pro- and anti-inflammatory cytokines expression in the newborn piglets with colibacteriosis against the background of the application of the complex medicine product Feronamin based on species-specific recombinant interferons. The study of the relative expression level of cytokine genes showed that the antibacterial drug Quinocol Plus reduced the expression level of IL-1α by 13.8 times, IL-1β – by 11.9 times, IL-8 – by 5.8 times, IL-10 – by 2.1 times, IFN-γ – by 11.3 times, did not affect IL-6, stimulated the expression of IFN-α genes by 3.8 times, TGF-β – by 7 times, while the combined use of the drugs Feronamin and Quinocol Plus suppressed the relative expression level of IL-1α by 23.0 times, IL-1β – by 31.1 times, IL-6 – by 10 times, IL-8 – by 3.5 times, IL-10 – by 3.3 times, IFN-γ – by 4.8 times, stimulated the expression of IFN-α genes by 1.9 times, TGF-β – by 3 times. Based on the study, the medicine product Feronamin can be recommended as an immunomodulator in the antibacterial treatment of colibacteriosis in newborn piglets to reduce stimulation of the immune response.
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