Effect of the drug feronamin on the level of pro- and anti-inflammatory cytokine genes expression in therapy of colibacteriosis in piglets

The article presents the data on the level of pro- and anti-inflammatory cytokines expression in the newborn piglets with colibacteriosis against the background of the application of the complex medicine product Feronamin based on species-specific recombinant interferons. The study of the relative expression level of cytokine genes showed that the antibacterial drug Quinocol Plus reduced the expression level of IL-1α by 13.8 times, IL-1β – by 11.9 times, IL-8 – by 5.8 times, IL-10 – by 2.1 times, IFN-γ – by 11.3 times, did not affect IL-6, stimulated the expression of IFN-α genes by 3.8 times, TGF-β – by 7 times, while the combined use of the drugs Feronamin and Quinocol Plus suppressed the relative expression level of IL-1α by 23.0 times, IL-1β – by 31.1 times, IL-6 – by 10 times, IL-8 – by 3.5 times, IL-10 – by 3.3 times, IFN-γ – by 4.8 times, stimulated the expression of IFN-α genes by 1.9 times, TGF-β – by 3 times. Based on the study, the medicine product Feronamin can be recommended as an immunomodulator in the antibacterial treatment of colibacteriosis in newborn piglets to reduce stimulation of the immune response.