Synthesis and characterization of hydroxy propyl methyl Cellulose/Copper nanobiocomposites for antibacterial and antioxidant smart materials

The synthesis of hydroxy propyl methyl cellulose (HPMC) /copper nanobiocomposites adopting a microwave treatment. In this study, HPMC and copper nitrate at various concentration were mixed and subjected to varying microwave treatment times (10, 20, 30, 40, 50 and 60 s). UV–Vis spectroscopy was employed to analyse the physicochemical characteristics of HPMC/Copper nanobiocomposites, with a maximal absorbance at 380 nm, indicating the formation copper nanoparticles within the HPMC matrix. The interaction between copper nanoparticles and HPMC was further confirmed through FT-IR analysis. The SEM analysis displayed microporous structures ranging from 5 to 14 µm in diameter, with an average pore size of 7.0 ± 2.0 nm. The compositional analysis was done with EDS mapping. TEM analysis revealed spherical shaped copper nanoparticles/ HPMC with an average particle size about 2.5 nm. Remarkably, these nanobiocomposites exhibited a broad-spectrum antibacterial activity, displaying minimal inhibitory concentrations against both Gram-negative and Gram-positive bacterium. Significantly, the assessment of antibacterial activity in HPMC/copper nanobiocomposites demonstrated their efficacy against both Escherichia coli and Staphylococcus aureus. The antibacterial properties holds significant implications for their potential applications of HPMC/ copper nanobiocomposites in the fields of food packaging and biomedicine.