Ru-Catalyzed Asymmetric Hydrogenation of α,β-Unsaturated Ketones via a Hydrogenation/Isomerization Cascade

Ru-catalyzed asymmetric hydrogenation of α-substituted α,β-unsaturated ketones has been developed for the enantioselective synthesis of chiral α-substituted secondary alcohols with high diastereo- and enantioselectivities (up to >99:1 dr，98% ee). Mechanistic...