Establishing the sensitivity and specificity of the gynaecological cancer distress screen

Charrlotte Seib,Emma Harbeck,Debra Anderson,Janine Porter-Steele,Caroline Nehill,Jasotha Sanmugarajah, Lewis Perrin, Catherine Shannon, Nimithri Cabraal, Bronwyn Jennings, Geoffrey Otton, Catherine Adams, Anne Mellon,Suzanne Chambers

PSYCHO-ONCOLOGY(2024)

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摘要
ObjectiveNuanced distress screening tools can help cancer care services manage specific cancer groups' concerns more efficiently. This study examines the sensitivity and specificity of a tool specifically for women with gynaecological cancers (called the Gynaecological Cancer Distress Screen or DT-Gyn).MethodsThis paper presents cross-sectional data from individuals recently treated for gynaecological cancer recruited through Australian cancer care services, partner organisations, and support/advocacy services. Receiver operating characteristics analyses were used to evaluate the diagnostic accuracy of the DT-Gyn against criterion measures for anxiety (GAD-7), depression (patient health questionnaire), and distress (IES-R and K10).ResultsOverall, 373 individuals aged 19-91 provided complete data for the study. Using the recognised distress thermometer (DT) cut-off of 4, 47% of participants were classified as distressed, while a cut-off of 5 suggested that 40% had clinically relevant distress. The DT-Gyn showed good discriminant ability across all measures (IES-R: area under the curve (AUC) = 0.86, 95% CI = 0.82-0.90; GAD-7: AUC = 0.89, 95% CI = 0.85-0.93; K10: AUC = 0.88, 95% CI = 0.85-0.92; PHQ-9: AUC = 0.85, 95% CI = 0.81-0.89) and the Youden Index suggested an optimum DT cut-point of 5.ConclusionsThis study established the psychometric properties of the DT-Gyn, a tool designed to identify and manage the common sources of distress in women with gynaecological cancers. We suggest a DT cut point >= 5 is optimal in detecting 'clinically relevant' distress, anxiety, and depression in this population.
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关键词
cancer,distress thermometer,gynaecological cancer,oncology,psycho-oncology,psychological support,routine screening,sensitivity,specificity
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