A sympathetic brake on gut GLP-1 release

Antonio J. López-Gambero, Victor Jouque,Daniela Cota

Neuron（2024）

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摘要

The brain-gut neurocircuitry is proving to be finely involved in a wide range of physiological functions. In this issue of Neuron, Ren et al.1 show that adrenergic signaling suppresses postprandial glucagon-like peptide 1 (GLP-1) secretion. This, in turn, raises circulating glucose levels and impairs brain glucose uptake and cognitive function.

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