Sickle cell trait in São Tomé e Príncipe: a population-based prevalence study in women of reproductive age
BMC Public Health(2024)
Abstract
Sickle Cell Disorder is Africa’s most prevalent genetic disease. Yet, it remains a neglected condition, with high mortality under-five, and a lack of population-based studies in the region. This is the first of its kind in São Tomé e Príncipe, aiming to estimate the prevalence of sickle cell trait and other haemoglobin variants in women of reproductive age and its associated factors. We conducted a cluster survey in 35 neighbourhoods. Haemoglobin was assessed through point-of-care capillary electrophoresis or high-performance liquid chromatography, and sociodemographic data through questionnaires. The weighted prevalence of sickle cell trait (HbAS) and HbC carriers was estimated with a 95
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Key words
Sickle cell disease,Haemoglobinopathies,Genetics,Cluster sampling,Sub-saharian Africa
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