Towards a mini-endoscope design with spatially selective excitation and imaging
BIOMEDICAL OPTICS EXPRESS(2024)
Abstract
We describe a mini-endoscope design that uses a new type of electrically tunable liquid crystal lens array enabling the dynamic increase of spatial resolution by adjusting the working distance in various zones of interest over a relatively large field of view (FoV) without mechanical movement. The characterization of the system is performed by using uniform fluorescent films, fluorescent micro spheres and a tissue sample expressing the fluorescent calcium indicator GCaMP6s. Lateral resolution of up to 2 mu m over the FoV between 300 mu m400 mu m is experimentally demonstrated.
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