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Persistent COVID-19 parosmia and olfactory loss post olfactory training: randomized clinical trial comparing central and peripheral-acting therapeutics

Elena Cantone,Luca D’Ascanio,Pietro De Luca,Dalila Roccamatisi, Ignazio La La Mantia,Michael J. Brenner,Arianna Di Stadio

European Archives of Oto-Rhino-Laryngology（2024）

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Abstract
Although COVID-19 anosmia is often transient, patients with persistent olfactory dysfunction (pOD) can experience refractory parosmia and diminished smell. This study evaluated four putative therapies for parosmia in patients with chronic COVID-19 olfactory impairment. After screening nasal endoscopy, 85 patients (49 female, 58
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Key words
Anosmia,Parosmia,Coronavirus long-COVID,Palmitoylethanolamide,Alpha lipoic acid
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