Photo- neuro- immuno- endocrinology: How the ultraviolet radiation regulates the body, brain, and immune system

we have gathered experimental and obser- vational evidence that UVR spectra of solar radiation have profound effects on systemic body homeostasis, which are defined by their wavelength and energy, nature of chromo- phores and of molecules produced in the barrier organ. Local physicochemical changes induced by solar radiation can lead to activation of local neuro- immuno- endocrine sensing and regulatory mechanisms with their projection to the central or systemic levels. While the precise mecha- nisms of these interactions remain to be explored, their health benefits and therapeutic implications can outweigh the negative effects if responsibly applied in an educated manner.