AntiDiarrhea and Central Nerval System Activity of Methanolic Extract of Holarrhenna antidysenterica (L.)

Abstract Diarrhea is a public health problem in developing countries. There are various useful plants plays important role to show antidiarrheal activity. In this study we are paying attention on the methanolic extract of Holarrhenna antidysenterica for its antidiarrheal effects on different anti-diarrheal animal models. At the same time we also observed whether it has any effects on the central nervous system. The antidiarrheal activity of methanol extract of seed of Holarrhena antidysenterica (L.) at dose 1200, 1400 and 1600 mg/kg was assessed on experimental animal and all these three doses decreased the total number of fecal dropping in castor oil induced diarrhoea. There were no significant results found in the inhibition of fluid accumulation in the intestine at 1400 and 1600 mg/kg dose. There was delayed the gastrointestinal transit time observed in mice for 1600 mg/kg dose of extract. The plant extract was also assessed on the central nervous system using a number of neuropharmacological experimental models in mice. The Extract at 1600 mg/kg showed significant decreased standing activity in the open field test. In hole board test, the number of movement and defecation significantly increased for the extract 1600 mg/kg but no activity for head dipping for both of these doses had seen. There was also increased the movement in hole cross test for the Extract 1600 mg/kg body weight.