Zfp36l1b is a marker of poor prognosis in Hepatocellular carcinoma suppression metastasis

Abstract Background & Aims: Given the pivotal role of Zfp36l1b in angiogenesis, proliferation and migration of endothelial cells, we aimed to explore its role in HCC metastasis. Methods: Zfp36l1b expressions in HCC tissues and cells were assessed by qRT-PCR, western blot and immunohistochemistry. The effect of Zfp36l1b on HCC metastasis was studied in vitroand in vivo. Results: Zfp36l1b was frequently down-regulated in HCC and its expression level was significantly associated with aggressive clinicopathological features and overall and disease-free survival of HCC patients after hepatectomy. Loss of Zfp36l1b markedly promoted HCC cells invasion and migration in vitro, and facilitated tumor metastasis in vivo. Conclusions: Zfp36l1b contributes to the development and progression of HCC as an anti-oncogene and may serve as a valuable prognostic marker for HCC patients.