Deciphering unique and shared interactions between the human gut microbiota and oral antidiabetic drugs

Huahui Ren,Zhun Shi,Fangming Yang,Shujie Wang,Fengyi Yuan,Tingting Li, Min Li,Jiahui Zhu,Junhua Li, Kui Wu,Yifei Zhang,Guang Ning,Karsten Kristiansen,Weiqing Wang,Yanyun Gu,Huanzi Zhong

IMETA（2024）

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摘要

The administration of oral antidiabetic drugs (OADs) to patients with type 2 diabetes elicits distinct and shared changes in the gut microbiota, with acarbose and berberine exhibiting greater impacts on the gut microbiota than metformin, vildagliptin, and glipizide. The baseline gut microbiota strongly associates with treatment responses of OADs. image

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