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Harnessing regulatory T cells to establish immune tolerance

Patrick Ho, Ellen Cahir-McFarland,Jason D. Fontenot, Tracey Lodie, Adel Nada,Qizhi Tang,Laurence A. Turka,Jeffrey A. Bluestone

SCIENCE TRANSLATIONAL MEDICINE（2024）

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Abstract
Engineered regulatory T (T-reg) cells have emerged as precision therapeutics aimed at inducing immune tolerance while reducing the risks associated with generalized immunosuppression. This Viewpoint highlights the opportunities and challenges for engineered T-reg cell therapies in treating autoimmune and other inflammatory diseases.
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