Mechanisms of norcantharidin against renal tubulointerstitial fibrosis
Pharmacological Reports(2024)
摘要
Renal tubulointerstitial fibrosis (RTIF) is a common feature and inevitable consequence of all progressive chronic kidney diseases, leading to end-stage renal failure regardless of the initial cause. Although research over the past few decades has greatly improved our understanding of the pathophysiology of RTIF, until now there has been no specific treatment available that can halt the progression of RTIF. Norcantharidin (NCTD) is a demethylated analogue of cantharidin, a natural compound isolated from 1500 species of medicinal insect, the blister beetle (Mylabris phalerata Pallas), traditionally used for medicinal purposes. Many studies have found that NCTD can attenuate RTIF and has the potential to be an anti-RTIF drug. This article reviews the recent progress of NCTD in the treatment of RTIF, with emphasis on the pharmacological mechanism of NCTD against RTIF.
更多查看译文
关键词
Norcantharidin (NCTD),Renal tubulointerstitial fibrosis (RTIF),Transforming growth factor-β1 (TGF-β1),Protein phosphatase 2A (PP2A),Tumor necrosis factor-like weak inducer of apoptosis (TWEAK),Long non-coding RNAs (lncRNAs),Nuclear factor-κB (NF-κB)
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要