Polo-like kinase 1 inhibition in KRAS-mutated metastatic colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research（2024）
摘要
Inhibition of Polo-like kinase 1 (Plk1) is a promising new target and therapeutic strategy in metastatic colorectal cancer, especially those with KRAS mutations. New data support further development of onvansertib, and highlights the role of circulating tumor DNA in phase 1 clinical trials.
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